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2019 \u5e74\u66b4\u53d1\u7684\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u80ba\u708e\u75ab\u60c5\u5f15\u53d1\u4e86\u5168\u4eba\u7c7b\u7684\u5065\u5eb7\u5371\u673a\u3002\u65b0\u51a0\u75c5\u6bd2\u5b58\u5728\u7caa\u53e3\u4f20\u64ad\u7684\u53ef\u80fd\u6027,\u75c5\u6bd2\u8fdb\u5165\u6c61\u6c34\u5904\u7406\u5382\u540e\u5e26\u6765\u4e8c\u6b21\u4f20\u64ad\u98ce\u9669,\u6c61\u6c34\u7684\u5b89\u5168\u5904\u7406\u5bf9\u75ab\u60c5\u9632\u63a7\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002\u9488\u5bf9\u5f53\u524d\u56fd\u5185\u5916\u5173\u4e8e\u65b0\u51a0\u75c5\u6bd2\u7684\u7814\u7a76\u73b0\u72b6,\u4e3b\u8981\u4ecb\u7ecd\u4e86\u65b0\u51a0\u75c5\u6bd2\u5728\u6c61\u6c34\u5904\u7406\u5382\u4e2d\u7684\u5206\u5e03\u7279\u5f81,\u5f52\u7eb3\u4e86\u65b0\u51a0\u75c5\u6bd2\u5728\u4e0d\u540c\u4ecb\u8d28\u4e2d\u7684\u6d53\u5ea6\u8303\u56f4\u3001\u8d4b\u5b58\u7279\u6027,\u5e76\u57fa\u4e8e\u5f53\u524d\u6c61\u6c34\u5904\u7406\u5382\u7684\u5904\u7406\u5de5\u827a,\u5206\u6790\u5e76\u603b\u7ed3\u4e86\u75c5\u6bd2\u5728\u4e0d\u540c\u4ecb\u8d28\u4e2d\u7684\u53bb\u9664\u673a\u7406\u3002\u9488\u5bf9\u6c61\u6c34\u5904\u7406\u8fc7\u7a0b\u4e2d\u75c5\u6bd2\u7684\u63a7\u5236\u63d0\u51fa\u5efa\u8bae,\u4ee5\u671f\u4e3a\u4eca\u540e\u533b\u7597\u5e9f\u6c34\u3001\u57ce\u9547\u6c61\u6c34\u4e2d\u75c5\u6bd2\u7684\u5904\u7406\u4ee5\u53ca\u6c61\u6c34\u5904\u7406\u5382\u7684\u7a33\u5b9a\u8fd0\u884c\u63d0\u4f9b\u53c2\u8003\u3002<\/p>\n\n\n\n

\u7814\u7a76\u4eae\u70b9<\/strong><\/p>\n\n\n\n

1\u3001\u5f52\u7eb3\u5e76\u603b\u7ed3\u4e86\u65b0\u51a0\u75c5\u6bd2\u5728\u6c61\u6c34\u5382\u4e0d\u540c\u4ecb\u8d28\u4e2d\u7684\u5206\u5e03\u7279\u5f81\u3001\u6d53\u5ea6\u8303\u56f4\u53ca\u8d4b\u5b58\u7279\u6027\uff1b<\/p>\n\n\n\n

2\u3001\u6839\u636e\u5f53\u524d\u6c61\u6c34\u5382\u5e38\u7528\u5904\u7406\u5de5\u827a\uff0c\u5206\u6790\u65b0\u51a0\u75c5\u6bd2\u53ca\u76f8\u5173\u75c5\u6bd2\u5728\u4e0d\u540c\u4ecb\u8d28\u3001\u4e0d\u540c\u6784\u7b51\u7269\u4e2d\u7684\u53bb\u9664\u673a\u7406\uff1b<\/p>\n\n\n\n

3\u3001\u603b\u7ed3\u4e86\u9488\u5bf9\u6c61\u6c34\u4e2d\u75c5\u6bd2\u7684\u5de5\u827a\u6d41\u7a0b\uff0c\u4e3a\u4eca\u540e\u6c61\u6c34\u4e2d\u75c5\u6bd2\u7684\u5904\u7406\u63d0\u4f9b\u53c2\u8003<\/p>\n\n\n\n

\u7531\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2(covid-19)\u611f\u67d3\u7684\u80ba\u708e\u75ab\u60c5\u4e25\u91cd\u5a01\u80c1\u4eba\u7c7b\u5065\u5eb7\uff0c\u8fd9\u662f\u5168\u7403\u6027\u7684\u516c\u5171\u5065\u5eb7\u5371\u673a\u3002\u65b0\u51a0\u75c5\u6bd2\u4e0esars\u8f83\u4e3a\u7c7b\u4f3c\uff0c\u5747\u5c5e\u4e8e\u5305\u819c\u75c5\u6bd2\uff0c\u62e5\u6709\u6781\u5f3a\u7684\u4f20\u67d3\u80fd\u529b\uff0c\u4e3b\u8981\u901a\u8fc7\u98de\u6cab\u4f20\u64ad\u548c\u63a5\u89e6\u4f20\u64ad\uff0c\u4e5f\u5b58\u5728\u7740\u6c14\u6eb6\u80f6\u53ca\u7caa\u53e3\u4f20\u64ad\u7684\u53ef\u80fd\u6027\u3002\u75c5\u6bd2\u53ef\u80fd\u901a\u8fc7\u611f\u67d3\u60a3\u8005\u7684\u7caa\u4fbf\u6392\u51fa\u4f53\u5916\uff0c\u8fdb\u800c\u901a\u8fc7\u6392\u6c34\u7cfb\u7edf\u8fdb\u5165\u6c61\u6c34\u5904\u7406\u7cfb\u7edf\u3002\u56e0\u6b64\uff0c\u6c61\u6c34\u5904\u7406\u5382\u4f5c\u4e3a\u6392\u6c34\u7cfb\u7edf\u7684\u7ec8\u7aef\u5904\u7406\u8bbe\u65bd\uff0c\u9632\u6b62\u75c5\u6bd2\u6269\u6563\u3001\u4fdd\u969c\u6c34\u73af\u5883\u5b89\u5168\u7684\u4efb\u52a1\u5c24\u4e3a\u91cd\u8981\u3002<\/p>\n\n\n\n

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1\u3001\u65b0\u51a0\u75c5\u6bd2\u5728\u6c61\u6c34\u5904\u7406\u5382\u7684\u5206\u5e03\u7279\u5f81<\/strong><\/p>\n\n\n\n

\u65b0\u51a0\u75c5\u6bd2\u968f\u7740\u533b\u9662\u5e9f\u6c34\u3001\u5e02\u653f\u6c61\u6c34\u7b49\u6392\u653e\u540e\uff0c\u7ecf\u6c61\u6c34\u7ba1\u9053\u6700\u7ec8\u8fdb\u5165\u6c61\u6c34\u5904\u7406\u5382\u3002\u4e00\u65b9\u9762\uff0c\u65b0\u51a0\u75c5\u6bd2\u901a\u8fc7\u5438\u9644\u4e0e\u89e3\u5438\u4f5c\u7528\u5b9e\u73b0\u5728\u6c34\u76f8\u4e0e\u56fa\u76f8\u95f4\u7684\u76f8\u4e92\u8fc1\u79fb\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u75c5\u6bd2\u4f1a\u968f\u7740\u5e9f\u6c34\u4e2d\u9897\u7c92\u7684\u96fe\u5316\u6ea2\u51fa\u81f3\u6c14\u6eb6\u80f6\u5185\uff0c\u5e76\u968f\u7740\u6c14\u6eb6\u80f6\u7684\u6c89\u964d\u4f5c\u7528\u53c8\u5c06\u65b0\u51a0\u75c5\u6bd2\u91cd\u65b0\u5e26\u56de\u6c61\u6c34\u4ee5\u53ca\u571f\u58e4\u4e2d(\u56fe1)\u3002\u5404\u56fd\u7814\u7a76\u8005\u4e3a\u66f4\u597d\u9632\u63a7\u75ab\u60c5\uff0c\u7814\u7a76\u65b0\u51a0\u75c5\u6bd2\u5728\u4e0d\u540c\u4ecb\u8d28\u4e2d\u7684\u8d4b\u5b58\u7279\u5f81\uff0c\u68c0\u6d4b\u5e76\u5b9a\u91cf\u65b0\u51a0\u75c5\u6bd2\u7684\u6d53\u5ea6\u8303\u56f4\uff0c\u5206\u6790\u65b0\u51a0\u75c5\u6bd2\u7684\u4f20\u64ad\u80fd\u529b\u4e0e\u5f71\u54cd\u60c5\u51b5\u3002\u4e0d\u540c\u4ecb\u8d28\u4e2d\u65b0\u51a0\u75c5\u6bd2\u7684\u5206\u5e03\u4e0e\u6d53\u5ea6\u5982\u88681\u6240\u793a\u3002<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n
\"\"<\/figure>\n\n\n\n

1.1 \u6c34\u76f8\u4e2d\u65b0\u51a0\u75c5\u6bd2\u7684\u5b58\u5728\u4e0e\u6d53\u5ea6<\/p>\n\n\n\n

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1.2 \u56fa\u76f8\u4e2d\u65b0\u51a0\u75c5\u6bd2\u7684\u5b58\u5728\u4e0e\u6d53\u5ea6<\/p>\n\n\n\n

\u65b0\u51a0\u75c5\u6bd2\u5728\u56fa\u76f8\u4e2d\u7684\u5206\u5e03\u4e3b\u8981\u96c6\u4e2d\u4e8e\u7caa\u4fbf\u3001\u6c61\u6ce5\u4e0e\u571f\u58e4\u4e2d\u3002\u4e00\u65b9\u9762\uff0c\u65b0\u51a0\u75c5\u6bd2\u4ee5\u7caa\u6c61\u6216\u5455\u5410\u7269\u7684\u5f62\u5f0f\u6392\u5165\u4e0b\u6c34\u7ba1\u9053\uff0c\u968f\u6c61\u6c34\u8fdb\u5165\u6c61\u6c34\u5904\u7406\u5382\u3002\u6c61\u6c34\u4e2d\u7684\u75c5\u6bd2\u901a\u8fc7\u5438\u9644\u4e0e\u6c89\u6dc0\u4f5c\u7528\u5206\u522b\u8f6c\u79fb\u81f3\u60ac\u6d6e\u9897\u7c92\u4e0e\u6c61\u6ce5\u4e2d\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u90e8\u5206\u542b\u6709\u75c5\u6bd2\u7684\u6c61\u6c34\/\u6c61\u6ce5\u7528\u4e8e\u519c\u7530\u704c\u6e89\u4e0e\u65bd\u80a5\uff0c\u75c5\u6bd2\u518d\u6b21\u8f6c\u79fb\u81f3\u571f\u58e4\u4e2d\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u6c61\u6c34\u96fe\u5316\u5f62\u6210\u7684\u75c5\u6bd2\u6c14\u6eb6\u80f6\u9897\u7c92\u4ee5\u6c89\u964d\u65b9\u5f0f\u8fdb\u5165\u571f\u58e4\uff0c\u5e76\u5728\u571f\u58e4\u4e2d\u6c89\u79ef\u3002<\/p>\n\n\n\n

\u7814\u7a76\u53d1\u73b0\uff0c\u65b0\u51a0\u75c5\u6bd2\u5728\u4e0d\u540c\u56fa\u76f8\u4e2d\u7684\u6d53\u5ea6\u6709\u6240\u4e0d\u540c\u3002\u7caa\u4fbf\u4e2d\u68c0\u6d4b\u51fa\u7684\u65b0\u51a0\u75c5\u6bd2\u542b\u91cf\u6700\u9ad8\uff0c\u7ea6\u4e3a106\uff5e108copies\/g\uff1b\u800c\u5728\u60a3\u8005\u6cbb\u7597\u540e\u4e00\u5468\uff0c\u7caa\u4fbf\u4e2d\u65b0\u51a0\u75c5\u6bd2\u542b\u91cf\u9010\u6e10\u964d\u81f3103copies\/g\u3002\u542b\u6709\u65b0\u51a0\u75c5\u6bd2\u7684\u7caa\u4fbf\u8fdb\u5165\u6c61\u6c34\u5904\u7406\u5382\u8fdb\u884c\u5904\u7406\u540e\uff0c\u65b0\u51a0\u75c5\u6bd2\u5728\u6c61\u6ce5\u4e2d\u7684\u6d53\u5ea6\u6709\u6240\u4e0b\u964d\uff0c\u542b\u91cf\u4e3a103\uff5e105copies\/ml\u3002balboa\u7b49\u53d1\u73b0\uff0c\u65b0\u51a0\u75c5\u6bd2\u9057\u4f20\u7269\u8d28\u5728\u67d0\u4e9b\u6c61\u6ce5\u4e2d\u7684\u6d53\u5ea6\u66f4\u9ad8\uff0c\u75c5\u6bd2\u9897\u7c92\u5bf9\u751f\u7269\u56fa\u4f53\u7684\u4eb2\u548c\u529b\u66f4\u5f3a\uff0c\u56e0\u6b64\uff0c\u65b0\u51a0\u75c5\u6bd2\u53ef\u4f18\u5148\u5728\u6c61\u6ce5\u4e2d\u8fdb\u884c\u76d1\u6d4b\u3002<\/p>\n\n\n\n

1.3 \u6c14\u76f8\u4e2d\u65b0\u51a0\u75c5\u6bd2\u7684\u5b58\u5728\u4e0e\u6d53\u5ea6<\/p>\n\n\n\n

\u65b0\u51a0\u75c5\u6bd2\u5728\u6c61\u6c34\u5904\u7406\u5382\u4e2d\u901a\u8fc7\u96fe\u5316\u4f5c\u7528\uff0c\u4ee5\u5fae\u751f\u7269\u6c14\u6eb6\u80f6\u7684\u5f62\u5f0f\u6c61\u67d3\u5468\u8fb9\u73af\u5883\uff0c\u5176\u542b\u91cf\u5728102copies\/m3\u5de6\u53f3\u3002\u5728\u91d1\u94f6\u6f6d\u533b\u9662\u3001\u706b\u795e\u5c71\u533b\u9662\u7684\u8c03\u8282\u6c60\u5185\uff0ccovid-19\u7684\u6c14\u6eb6\u80f6\u542b\u91cf\u5206\u522b\u4e3a285\u3001603 copies\/m3\u3002\u56e0\u6b64\uff0c\u6c61\u6c34\u5904\u7406\u7ad9\u8bbe\u8ba1\u8fc7\u7a0b\u4e2d\u5c24\u5176\u9700\u8981\u6ce8\u91cd\u6784\u7b51\u7269\u5bc6\u5c01\u6548\u679c\uff0c\u51cf\u5c11\u6c61\u6c34\u5728\u63d0\u5347\u3001\u66dd\u6c14\u3001\u6405\u62cc\u7b49\u8fc7\u7a0b\u4e2d,\u65b0\u51a0\u75c5\u6bd2\u4ee5\u6c14\u6eb6\u80f6\u5f62\u5f0f\u91ca\u653e\u81f3\u5468\u8fb9\u73af\u5883\u3002<\/p>\n\n\n\n

\u7814\u7a76\u8868\u660e\uff0c\u5206\u79bb\u611f\u67d3\u6027\u7684\u65b0\u51a0\u75c5\u6bd2\u7c92\u5b50\u9700\u8981\u66f4\u9ad8\u7684\u75c5\u6bd2\u542b\u91cf(\u5927\u4e8e106copies\/ml)\u3002\u56e0\u6b64\uff0c\u5c3d\u7ba1\u5c11\u6570\u7814\u7a76\u6210\u529f\u5730\u4ece\u7caa\u4fbf\u6837\u672c\u4e2d\u5206\u79bb\u51fa\u611f\u67d3\u6027\u65b0\u51a0\u75c5\u6bd2\uff0c\u4f46\u6c34\u548c\u6c14\u6eb6\u80f6\u4e2d\u5c1a\u96be\u4ee5\u5206\u79bb\u51fa\u611f\u67d3\u6027\u7684\u65b0\u51a0\u75c5\u6bd2\uff0c\u56e0\u6b64\uff0c\u6700\u5c0f\u611f\u67d3\u5242\u91cf\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\uff0c\u76f8\u6bd4\u4e8e\u7f3a\u4e4f\u611f\u67d3\u6027\u75c5\u6bd2\u7c92\u5b50\uff0c\u96be\u4ee5\u5206\u79bb\u51fa\u5b8c\u6574\u7684\u5305\u819c\u75c5\u6bd2\u7c92\u5b50\u662f\u66f4\u4e3a\u91cd\u8981\u7684\u539f\u56e0\u3002\u7136\u800c\uff0cfoladori\u7b49\u5728\u5173\u4e8e\u65b0\u51a0\u75c5\u6bd2\u5728\u6c61\u6c34\u5904\u7406\u7cfb\u7edf\u7684\u7814\u7a76\u8868\u660e\uff0c\u5c3d\u7ba1\u5728\u5904\u7406\u8fc7\u7a0b\u4e2d\u65b0\u51a0\u75c5\u6bd2\u8f7d\u91cf\u663e\u8457\u51cf\u5c11\uff0c\u4f46\u4ecd\u53ef\u4ee5\u68c0\u6d4b\u5230\u57fa\u56e0\u7247\u6bb5\u3002\u56e0\u6b64\uff0c\u4ecd\u9700\u8981\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u6765\u8bc4\u4f30\u65b0\u51a0\u75c5\u6bd2\u5728\u6c34\u5faa\u73af\u4e2d\u53ef\u80fd\u9020\u6210\u7684\u98ce\u9669\u3002\u5728\u8fd9\u4e4b\u524d\uff0c\u9488\u5bf9\u6c61\u6c34\u7684\u5b89\u5168\u5904\u7406\u5fc5\u4e0d\u53ef\u5c11\u3002<\/p>\n\n\n\n

2\u3001\u65b0\u51a0\u75c5\u6bd2\u5728\u6c61\u6c34\u5904\u7406\u5382\u7684\u53bb\u9664\u7279\u6027<\/strong><\/p>\n\n\n\n

2.1 \u6c61\u6c34\u5904\u7406<\/p>\n\n\n\n

2.1.1 \u4e00\u7ea7\u5904\u7406<\/p>\n\n\n\n

\u6c61\u6c34\u7684\u4e00\u7ea7\u5904\u7406\u662f\u622a\u7559\u9664\u6e23\u3001\u6c89\u6dc0\u56fa\u4f53\u7b49\u7269\u7406\u4f5c\u7528\u7684\u5904\u7406\u8fc7\u7a0b\uff0c\u901a\u8fc7\u5bf9\u9644\u7740\u75c5\u6bd2\u7684\u60ac\u6d6e\u7269\u8fdb\u884c\u6c89\u6dc0\u5206\u79bb\u6765\u53bb\u9664\u75c5\u6bd2\u3002\u4e00\u822c\u6765\u8bf4\uff0c\u4e00\u7ea7\u5904\u7406\u5bf9\u75c5\u6bd2\u7684\u53bb\u9664\u7387\u8f83\u4f4e\uff0clucena\u7b49\u7814\u7a76\u4e86\u4e0d\u540c\u6c61\u6c34\u5904\u7406\u5382\u4e00\u7ea7\u5904\u7406\u8fc7\u7a0b\u5bf9\u4e0d\u540c\u75c5\u6bd2\u8fc7\u7a0b\uff0c\u5176\u53bb\u9664\u7387\u4e3a0.31\uff5e0.44 log\u3002<\/p>\n\n\n\n

2.1.2 \u4e8c\u7ea7\u5904\u7406<\/p>\n\n\n\n

\u897f\u7535\u4e1c\u9001\u5728\u4fc3\u8fdb\u4e91\u5357\u8fc8\u4e0a\u201c\u7535\u529b\u5f3a\u7701\u201d\u4e4b\u8def\uff0c\u6781\u5927\u5e26\u52a8\u7701\u5185\u7535\u529b\u5de5\u4e1a\u53d1\u5c55\u7684\u540c\u65f6\uff0c\u4e5f\u62c9\u52a8\u4e86\u7701\u5185\u7164\u70ad\u3001\u5efa\u6750\u3001\u8fd0\u8f93\u3001\u94a2\u94c1\u548c\u7b2c\u4e09\u4ea7\u4e1a\u7684\u9ad8\u901f\u53d1\u5c55\u3002\u76ee\u524d\uff0c\u897f\u7535\u4e1c\u9001\u6700\u5927\u9001\u7535\u80fd\u529b\u8fbe2870\u4e07\u5343\u74e6\uff0c\u8f83\u9001\u7535\u4e4b\u521d\u768425\u4e07\u5343\u74e6\u589e\u957f115\u500d\uff0c\u5e74\u8f93\u9001\u7535\u91cf\u8f83\u6700\u521d\u76845.5\u4ebf\u5343\u74e6\u65f6\u589e\u957f225\u500d\u3002\u968f\u7740\u6f9c\u6ca7\u6c5f\u4e0a\u6e38\u68af\u7ea7\u7535\u7ad9\u9001\u51fa\u5de5\u7a0b\uff0c\u4ee5\u53ca\u4e4c\u4e1c\u5fb7\u9001\u7535\u5e7f\u4e1c\u5e7f\u897f\u5de5\u7a0b\u7684\u52a0\u5feb\u5efa\u6210\uff0c\u52302020\u5e74\uff0c\u4e91\u5357\u7701\u201c\u897f\u7535\u4e1c\u9001\u201d\u80fd\u529b\u5c06\u8fbe\u52303615\u4e07\u5343\u74e6\u3002<\/p>\n\n\n\n

\u6c61\u6c34\u7684\u4e8c\u7ea7\u5904\u7406\u5373\u751f\u7269\u5904\u7406\u8fc7\u7a0b\uff0c\u5176\u4e2d\uff0c\u6d3b\u6027\u6c61\u6ce5\u6cd5\u88ab\u8ba4\u4e3a\u662f\u51cf\u5c11\u75c5\u6bd2\u6700\u6709\u6548\u7684\u65b9\u6cd5\uff0c\u5176\u53ef\u901a\u8fc7\u7ec6\u83cc\u7b49\u5fae\u751f\u7269\u5bf9\u75c5\u6bd2\u7684\u6355\u98df\u548c\u9176\u5206\u89e3\uff0c\u8fbe\u5230\u51cf\u5c11\u5e76\u706d\u6d3b\u75c5\u6bd2\u7684\u76ee\u7684\u3002lucena\u7b49\u7814\u7a76\u53d1\u73b0\u542b\u75c5\u6bd2\u7684\u6c61\u6c34\u7ecf\u6d3b\u6027\u6c61\u6ce5\u6cd5\u5904\u7406\u540e\uff0c\u75c5\u6bd2\u51cf\u5c11\u4e861.0\uff5e1.6 log\uff0c\u6bd4\u4e00\u7ea7\u5904\u7406\u5de5\u827a\u591a\u51cf\u5c11\u4e86\u7ea61 log\u3002<\/p>\n\n\n\n

\u819c\u751f\u7269\u53cd\u5e94\u5668(mbr)\u4f5c\u4e3a\u5e38\u7528\u7684\u4e8c\u7ea7\u5904\u7406\u8bbe\u65bd\uff0c\u662f\u751f\u7269\u5904\u7406\u548c\u819c\u8fc7\u6ee4\u7684\u96c6\u6210\uff0c\u80fd\u5728\u8f83\u77ed\u7684\u63a5\u89e6\u65f6\u95f4\u5185\u8fbe\u5230\u5f88\u597d\u7684\u5fae\u751f\u7269\u706d\u6d3b\u6548\u679c\u3002owen\u7b49\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u7ecfmbr\u5904\u7406\u540e\uff0c\u51fa\u6c34\u4e2d\u80a0\u9053\u75c5\u6bd2\u7b49\u75c5\u539f\u5fae\u751f\u7269\u90fd\u4f4e\u4e8e\u68c0\u6d4b\u9650\uff0c\u53bb\u9664\u7387\u4e3a6\uff5e8 log\u3002mbr\u5bf9\u75c5\u6bd2\u7684\u53bb\u9664\u4f5c\u7528\u4e0d\u4ec5\u4f53\u73b0\u5728\u6d3b\u6027\u6c61\u6ce5\u5bf9\u75c5\u6bd2\u7684\u706d\u6d3b\uff0c\u819c\u8868\u9762\u7684\u6ee4\u997c\u5c42\u548c\u51dd\u80f6\u5c42\u5728\u75c5\u6bd2\u7684\u622a\u7559\u4e2d\u8d77\u4e86\u91cd\u8981\u7684\u4f5c\u7528\u3002<\/p>\n\n\n\n

\u79fb\u52a8\u5e8a\u751f\u7269\u819c\u53cd\u5e94\u5668(mbbr)\u662f\u53e6\u4e00\u79cd\u6c61\u6c34\u5904\u7406\u5382\u5e38\u91c7\u7528\u7684\u5904\u7406\u8bbe\u65bd\uff0c\u5177\u6709\u6c61\u6ce5\u4ea7\u91cf\u5c11\u3001\u8fd0\u884c\u76f8\u5bf9\u7a33\u5b9a\u7b49\u4f18\u70b9\u3002bauer\u7b49\u7814\u7a76\u8868\u660e\uff0c\u6c14\u6eb6\u80f6\u7684\u6392\u653e\u7a0b\u5ea6\u4e0e\u53cd\u5e94\u5668\u7c7b\u578b\u6709\u5173\uff0c\u751f\u7269\u819c\u53cd\u5e94\u5668(mbr)\u663e\u793a\u51fa\u6bd4\u6d3b\u6027\u6c61\u6ce5\u7684\u66dd\u6c14\u53cd\u5e94\u5668\u66f4\u5c11\u7684\u6c14\u6eb6\u80f6\u6392\u653e\uff0cmbbr\u4f5c\u4e3ambr\u7684\u4e00\u79cd\uff0c\u4f53\u73b0\u51fa\u4e86\u4e00\u5b9a\u7684\u4f18\u8d8a\u6027\u3002\u7531\u4e8embbr\u4ea7\u6ce5\u7387\u4f4e\uff0c\u540c\u65f6\u964d\u4f4e\u4e86\u75c5\u6bd2\u5728\u6c61\u6ce5\u53ca\u571f\u58e4\u4e2d\u7684\u8d4b\u5b58\u53ca\u8fc1\u79fb\u7684\u7a0b\u5ea6\u3002<\/p>\n\n\n\n

\u751f\u7269\u5904\u7406\u4e00\u65b9\u9762\u901a\u8fc7\u7ec6\u83cc\u5bf9\u75c5\u6bd2\u7684\u4f5c\u7528\u5c06\u75c5\u6bd2\u706d\u6d3b\uff0c\u53e6\u4e00\u65b9\u9762\u7531\u4e8e\u6709\u6548\u964d\u89e3\u6c61\u6c34\u4e2d\u7684\u6709\u673a\u56fa\u4f53\uff0c\u5b58\u5728\u5c06\u5438\u9644\u4e8e\u56fa\u4f53\u4e0a\u7684\u75c5\u6bd2\u91cd\u65b0\u8f6c\u79fb\u81f3\u6c34\u76f8\u7684\u53ef\u80fd\u6027\u3002randazzo\u7b49\u7814\u7a76\u53d1\u73b0\uff0c\u5728\u6c61\u6c34\u5904\u7406\u5382\u5e38\u89c4\u6d3b\u6027\u6c61\u6ce5\u5904\u7406\u540e\uff0c\u4ecd\u670911%\u7684\u6837\u54c1\u4e2d\u65b0\u51a0\u75c5\u6bd2rna\u5448\u73b0\u9633\u6027\uff1bzhang\u7b49\u540c\u6837\u901a\u8fc7\u68c0\u6d4b\u53d1\u73b0\uff0c\u706b\u795e\u5c71\u5728\u4e00\u7ea7\u8c03\u8282\u6c60\u8fdb\u884c\u6d88\u6bd2\u5904\u7406\u540e\uff0c\u68c0\u6d4b\u5230\u65b0\u51a0\u75c5\u6bd2\u542b\u91cf\u4e3a633 copies\/l\uff0c\u7d27\u968f\u5176\u540e\u7684\u5316\u7caa\u6c60\u4e0e\u4e8c\u7ea7\u8c03\u8282\u6c60\u5747\u672a\u68c0\u6d4b\u5230\u65b0\u51a0\u75c5\u6bd2\u7684\u5b58\u5728\uff0c\u800c\u5728mbbr\u53cd\u5e94\u5668\u4e2d\u5076\u7136\u4f1a\u68c0\u6d4b\u5230\u65b0\u51a0\u75c5\u6bd2\uff0c\u5176\u539f\u56e0\u53ef\u80fd\u662f\u75c5\u6bd2\u8131\u79bb\u56fa\u4f53\u540e\u7684\u91cd\u65b0\u91ca\u653e\u3002<\/p>\n\n\n\n

2.1.3 \u4e09\u7ea7\u5904\u7406<\/p>\n\n\n\n

\u6c61\u6c34\u7684\u4e09\u7ea7\u5904\u7406\u662f\u901a\u8fc7\u6df7\u51dd\u6c89\u6dc0\u3001\u819c\u5206\u79bb\u7b49\u65b9\u5f0f\u5bf9\u6c61\u67d3\u7269\u8fdb\u884c\u8fdb\u4e00\u6b65\u53bb\u9664\u7684\u8fc7\u7a0b\u3002\u5728\u6df7\u51dd\u8fc7\u7a0b\u4e2d\uff0c\u75c5\u6bd2\u53ef\u4ee5\u7ed3\u5408\u6b63\u5728\u5f62\u6210\u7684\u7d6e\u4f53\u5e76\u5438\u9644\u81f3\u5176\u8868\u9762\uff0c\u968f\u540e\u5176\u4e0e\u7d6e\u4f53\u91cd\u529b\u6c89\u964d\u540e\u88ab\u53bb\u9664\u3002\u7814\u7a76\u8868\u660e\uff0c\u5728\u94dd\u6df7\u51dd\u5242\u6c34\u89e3\u8fc7\u7a0b\u4e2d\u5f62\u6210\u7684\u805a\u5408\u7269\u5bf9\u75c5\u6bd2\u5177\u6709\u66f4\u5927\u7684\u5438\u5f15\u529b\uff0c\u5728\u7535\u8377\u4e2d\u548c\u7684\u8fc7\u7a0b\u4e2d\uff0c\u75c5\u6bd2\u4e0e\u6b63\u5728\u5f62\u6210\u7684\u805a\u5408\u7269\u5171\u6c89\u6dc0\uff0c\u75c5\u6bd2\u9010\u6e10\u5931\u53bb\u6d3b\u6027\u4e0e\u4f20\u67d3\u6027\uff0c\u800c\u76f8\u6bd4\u65e0\u673a\u6df7\u51dd\u5242\uff0c\u6295\u52a0\u805a\u5408\u6c2f\u5316\u94dd\u80fd\u4f7f\u53bb\u9664\u6548\u679c\u66f4\u4f73\uff0c\u5176\u539f\u56e0\u662f\u5f62\u6210\u66f4\u591a\u6570\u91cf\u5bf9\u75c5\u6bd2\u5177\u6709\u5f3a\u5927\u5438\u5f15\u529b\u7684\u4e2d\u95f4\u805a\u5408\u7269\u3002\u94c1\u76d0\u662f\u53e6\u4e00\u79cd\u5e7f\u6cdb\u4f7f\u7528\u7684\u6df7\u51dd\u5242\uff0c\u4e09\u4ef7\u94c1\u76d0\u663e\u793a\u51fa\u4e0e\u94dd\u6df7\u51dd\u5242\u76f8\u4f3c\u7684\u53bb\u9664\u6548\u679c\u53ca\u4f5c\u7528\u673a\u7406\u3002\u7136\u800c\u4e5f\u6709\u7814\u7a76\u53d1\u73b0\uff0c\u4e8c\u6c2f\u5316\u94c1\u5316\u5b66\u6df7\u51dd\u8fc7\u7a0b\u540c\u6837\u53ef\u4ee5\u4f7f\u75c5\u6bd2\u5931\u6d3b\uff0c\u4f46\u5176\u4e3b\u8981\u4f5c\u7528\u6e90\u4e8e\u4e8c\u4ef7\u94c1\u88ab\u6c27\u5316\u3002\u819c\u5206\u79bb\u4f5c\u4e3a\u4e00\u79cd\u9ad8\u6548\u7684\u6c34\u5904\u7406\u6280\u672f\uff0c\u53ef\u4ee5\u901a\u8fc7\u7269\u7406\u622a\u7559\u663e\u8457\u5730\u8fdb\u4e00\u6b65\u51cf\u5c11\u75c5\u6bd2\u6570\u91cf\uff0c\u4e3b\u8981\u901a\u8fc7\u75c5\u6bd2\u4e0e\u819c\u6750\u6599\u95f4\u7684\u9759\u7535\u4f5c\u7528\u4ee5\u53ca\u6ee4\u997c\u5c42\u7684\u5438\u9644\u4f5c\u7528\u5b9e\u73b0\u75c5\u6bd2\u7684\u53bb\u9664\u3002\u53cd\u6e17\u900f\u6280\u672f\u76f8\u6bd4\u5fae\u6ee4\u3001\u8d85\u6ee4\u663e\u793a\u51fa\u66f4\u9ad8\u7684\u75c5\u6bd2\u53bb\u9664\u7387\uff0c\u4f46\u7531\u4e8e\u6210\u672c\u8f83\u9ad8\u3001\u5355\u4f4d\u9762\u79ef\u4ea7\u6c34\u6548\u7387\u4f4e\uff0c\u8be5\u6280\u672f\u8f83\u5c11\u5f97\u5230\u5e94\u7528\u3002<\/p>\n\n\n\n

2.1.4 \u6d88\u6bd2\u5904\u7406<\/p>\n\n\n\n

\u7531\u4e8e\u9897\u7c92\u7684\u4fdd\u62a4\u4f5c\u7528\uff0c\u6c61\u6c34\u5728\u8fdb\u884c\u751f\u7269\u5904\u7406\u4e4b\u540e\uff0c\u75c5\u6bd2\u5c1a\u672a\u5b8c\u5168\u88ab\u53bb\u9664\u800c\u91cd\u65b0\u91ca\u653e\u81f3\u6c34\u76f8\u4e2d\uff0c\u9700\u63a5\u5165\u540e\u7eed\u6d88\u6bd2\u6c60\uff0c\u5bf9\u51fa\u6c34\u8fdb\u884c\u4e8c\u7ea7\u6d88\u6bd2\uff0c\u786e\u4fdd\u6740\u706d\u5269\u4f59\u75c5\u6bd2\u3002\u4e8c\u7ea7\u6d88\u6bd2\u540c\u6837\u5e38\u91c7\u7528\u6c2f\u6d88\u6bd2\uff0c\u4ece\u9884\u6d88\u6bd2\u5230\u5c3e\u6c34\u6d88\u6bd2\u7684\u5168\u5de5\u827a\u505c\u7559\u65f6\u95f4\u4e0d\u5c0f\u4e8e2 d\uff0c\u786e\u4fdd\u51fa\u6c34\u4f59\u6c2f\u5927\u4e8e6.5 mg\/l\uff0c\u4fdd\u969c\u7cfb\u7edf\u51fa\u6c34\u7684\u5b89\u5168\u6027\u3002zhang\u7b49\u5728\u533b\u9662\u6d88\u6bd2\u540e\u7684\u5e9f\u6c34\u4e2d\u672a\u68c0\u6d4b\u5230\u65b0\u51a0\u75c5\u6bd2\uff0c\u8bc1\u5b9e\u4e86\u4e8c\u7ea7\u6d88\u6bd2\u51fa\u6c34\u540e\u65b0\u51a0\u75c5\u6bd2\u7684\u5b8c\u5168\u706d\u6740\u3002wang\u7b49\u5728\u533b\u9662\u5e9f\u6c34\u4e2d\u75c5\u6bd2\u7684\u76d1\u6d4b\u60c5\u51b5\u8868\u660e\uff0c\u5c3d\u7ba1\u9884\u6d88\u6bd2\u6c60\u5165\u53e3\u7684\u6c61\u6c34\u6837\u54c1\u65b0\u51a0\u75c5\u6bd2rna\u5448\u73b0\u9633\u6027\uff0c\u7ecf\u4e00\u7ea7\u6d88\u6bd2\u540e\u6837\u54c1\u5448\u5f31\u9633\u6027\uff0c\u4f46\u662f\u6700\u540e\u4e00\u4e2a\u6d88\u6bd2\u6c60\u51fa\u53e3\u7684\u6c61\u6c34\u6837\u54c1\u5448\u73b0\u9634\u6027\uff0c\u5c55\u793a\u4e86\u4e8c\u7ea7\u6d88\u6bd2\u5de5\u827a\u5bf9\u4e8e\u75c5\u6bd2\u706d\u6740\u7684\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n\n\n\n

\u9664\u6c2f\u6d88\u6bd2\u4e4b\u5916\uff0c\u81ed\u6c27\u6d88\u6bd2\u548c\u7d2b\u5916\u6d88\u6bd2\u4e5f\u5e38\u7528\u4e8e\u6c61\u6c34\u6d88\u6bd2\u8fc7\u7a0b\uff0c\u4e8c\u8005\u5bf9sars\u75c5\u6bd2\u5747\u6709\u8f83\u597d\u7684\u53bb\u9664\u6548\u679c\uff0c\u4e3a\u75ab\u60c5\u671f\u95f4\u65b0\u51a0\u75c5\u6bd2\u7684\u9632\u63a7\u63d0\u4f9b\u4e86\u53c2\u8003\uff0c\u4f46\u81ed\u6c27\u7684\u8fd0\u884c\u6210\u672c\u66f4\u9ad8\uff0c\u7d2b\u5916\u6d88\u6bd2\u53d7\u6c34\u4e2d\u60ac\u6d6e\u7269\u6d53\u5ea6\u5f71\u54cd\u8f83\u5927\uff0c\u56e0\u6b64\uff0c\u4e8c\u8005\u5e94\u7528\u76f8\u5bf9\u53d7\u9650\u3002<\/p>\n\n\n\n

\u7efc\u4e0a\uff0c\u9488\u5bf9\u65b0\u51a0\u75c5\u6bd2\u5728\u6c61\u6c34\u5904\u7406\u5382\u7684\u5206\u5e03\u7279\u5f81\uff0c\u6c61\u6c34\u5904\u7406\u5de5\u827a\u91c7\u7528\u4e00\u7ea7\u6d88\u6bd2-\u751f\u7269\u5904\u7406-\u4e8c\u7ea7\u6d88\u6bd2\u7684\u5904\u7406\u6d41\u7a0b(\u56fe2)\uff0c\u901a\u8fc7\u6c34\u76f8\u6d88\u6740\u5c06\u6570\u91cf\u7ea7\u4e3a106copies\/l\u7684\u75c5\u6bd2\u8fdb\u884c\u90e8\u5206\u6d88\u6740\uff0c\u63a5\u7740\u91c7\u7528\u751f\u7269\u53cd\u5e94\u5c06\u56fa\u4f53\u9897\u7c92\u6d88\u89e3\uff0c\u4f7f\u75c5\u6bd2\u8131\u843d\u800c\u91ca\u653e\u81f3\u6c34\u76f8\u4e2d\uff0c\u6700\u540e\u7ecf\u4e8c\u6b21\u6d88\u6bd2\u5b9e\u73b0\u5bf9\u6c34\u76f8\u4e0e\u56fa\u76f8\u4e2d\u65b0\u51a0\u75c5\u6bd2\u7684\u5b8c\u5168\u6740\u706d\uff0c\u8fbe\u5230\u4e86\u826f\u597d\u7684\u53bb\u9664\u6548\u679c\u3002<\/p>\n\n\n\n

\"1.png\"<\/figure>\n\n\n\n

2.2 \u6c61\u6ce5\u5904\u7406<\/p>\n\n\n\n

\u6c61\u6c34\u5904\u7406\u5382\u5728\u6c61\u6ce5\u5916\u8fd0\u5904\u7406\u4e4b\u524d\uff0c\u91c7\u7528\u751f\u77f3\u7070\u6d88\u6bd2\u7684\u65b9\u5f0f\uff0c\u51cf\u5c11\u6c61\u6ce5\u5728\u5916\u8fd0\u8fc7\u7a0b\u75c5\u6bd2\u6ea2\u51fa\u4f20\u64ad\u7684\u98ce\u9669\u3002\u751f\u77f3\u7070\u6cd5\u662f\u4e00\u79cd\u901a\u8fc7\u6dfb\u52a0\u78b1\u6027\u6750\u6599\u5c06ph\u503c\u63d0\u9ad8\u81f312\u4ee5\u4e0a\uff0c\u4ece\u800c\u706d\u6d3b\u75c5\u6bd2\u7684\u65b9\u6cd5\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u751f\u77f3\u7070\u80fd\u57282\uff5e24 h\u5c06\u6c61\u6ce5\u4e2d\u591a\u79cd\u75c5\u6bd2\u548c\u75c5\u539f\u5fae\u751f\u7269\u706d\u6d3b\u3002\u6b64\u5916\uff0c\u6dfb\u52a0\u77f3\u7070\u5f15\u8d77\u7684\u6e29\u5ea6\u5347\u9ad8\u4e5f\u662f\u6740\u706d\u75c5\u539f\u5fae\u751f\u7269\u7684\u91cd\u8981\u539f\u56e0\u3002\u706b\u795e\u5c71\u6c61\u6c34\u5904\u7406\u7ad9\u91c7\u7528\u751f\u77f3\u7070\u6d88\u6bd2\uff0c\u4e0d\u4ec5\u5728\u6c61\u6ce5\u5916\u8fd0\u524d\u8d77\u5230\u4e86\u9884\u6d88\u6bd2\u4f5c\u7528\uff0c\u800c\u4e14\u8131\u6c34\u6027\u80fd\u4e5f\u5f97\u5230\u4e86\u63d0\u9ad8\u3002<\/p>\n\n\n\n

2.3 \u5c3e\u6c14\u5904\u7406<\/p>\n\n\n\n

\u4e3a\u6709\u6548\u964d\u4f4e\u75c5\u6bd2\u6c14\u6eb6\u80f6\u4f20\u64ad\u7684\u98ce\u9669\uff0c\u5c3e\u6c14\u7684\u63a7\u5236\u81f3\u5173\u91cd\u8981\uff0c\u9700\u8fdb\u884c\u5c01\u95ed\u6536\u96c6\u3002\u5c3e\u6c14\u5904\u7406\u4e3b\u8981\u5305\u62ec\u6d3b\u6027\u70ad\u5438\u9644\u6cd5\u3001\u7d2b\u5916\u5149\u89e3\u6cd5\u3001\u751f\u7269\u6cd5\u7b49\u65b9\u5f0f\u3002<\/p>\n\n\n\n

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3\u3001\u7ed3\u8bba\u4e0e\u5efa\u8bae<\/strong><\/p>\n\n\n\n

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